Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Cell. 1996 . Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation (Stein et al. 2001) .sNetrin binds exclusively to the fifth fibronectin type III repeat of DCC (Geisbrecht et al. 2003)

The attractive responses of Xenopus spinal axons to netrin-1, which are mediated by DCC are converted to repulsion by expression of UNC5. (Hong et al. 1999) found that netrin-1 triggers the formation of a receptor complex of DCC and UNC5 which derepresses the interaction between their cytoplasmic domains, thereby converting DCC-mediated attraction to UNC5/DCC-mediated repulsion

Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains. Mol Cell Neurosci. 2006