Summary: (from NCBI-Entrez) ..[read more]This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal tr
Liaw CW, et al. (Endocrinology. 1996 ) cloned two CRH receptors and the CRF- and sauvagine-induced accumulation of intracellular cAMP could be competitively inhibited by the CRF receptor antagonist D-Phe-CRF.
Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.
Proc Natl Acad Sci U S A. 2001
Receptor CRHR1 interacts with:
All interactions in Receptor family ( 7TM|B|Polypeptide )
Gene Expression data