Summary: (from NCBI-Entrez) ..[read more]The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin gener
Receptor THBD interacts with:
Receptor PROCR - PROTEIN C RECEPTOR, ENDOTHELIAL (EPCR)andLigand PF4 - PLATELET FACTOR 4 (CHEMOKINE (C-X-C MOTIF) L ...[read more..]
Platelet factor 4 binds to glycanated forms of thrombomodulin and to protein C. A potential mechanism for enhancing generation of activated protein C.
J Biol Chem. 1997