Summary: (from NCBI-Entrez) ..[read more]This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be
Yu G, et al. (Nature. 2000)report that nicastrin and presenilins are likely to be functional components, modulating presenilin-mediated notch/glp-1 signal transduction.