Summary: (from NCBI-Entrez) ..[read more]Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the
The RET receptor tyrosine kinase is activated by binding to a ligand complex formed by a member of the glial cell line-derived neurotrophic factor (GDNF) family of neurotrophic factors bound to its cognate GDNF-family receptor-alpha (GFR alpha) glycosylphosphatidylinositol-linked co-receptor (Kjaer & Ibanez 2003). (Saarma et al. 2000)undefined
TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.
In cells transfected with GRFA1 and RET, both GDNF and neurturin activate downstream signaling. (Neuron. 1997) .
GFRA1 - GDNF FAMILY RECEPTOR ALPHA 1 ISOFORM A PREPROPROTEIN
Family:GPI-anchored
Receptor GFRA1 interacts with:
All interactions in Receptor family ( GPI-anchored )
Gene Expression data