Summary: (from NCBI-Entrez) ..[read more]The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. [provided
The GDNF ligands (GDNF, Neurturin [NTN], and Persephin [PSP]) signal through a high-affinity binding component (GFRalpha-1-GFRalpha-4) and a common signaling component - RET. Artemin, a member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex (Baloh et al. 1998).
Receptor GFRA3 interacts with:
All interactions in Receptor family ( GPI-anchored )
Gene Expression data