Summary: (from NCBI-Entrez) ..[read more]The sperm-specific protein Izumo, named for a Japanese shrine dedicated to marriage, is essential for sperm-egg plasma membrane binding and fusion (Inoue et al., 2005 [PubMed 15759005]).[supplied by OMIM, Mar 2008]
The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. Nature. 2005 . The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. Recently, CD9 on the egg membrane was found to be essential for fusion, but sperm-related fusion factors remain unknown. Here, by using a fusion-inhibiting monoclonal antibody and gene cloning, we identify a mouse sperm fusion-related antigen and show that the antigen is a novel immunoglobulin superfamily protein. We have termed the gene Izumo and produced a gene-disrupted mouse line.
All interactions in Receptor family ( Other )
Gene Expression data