Summary: (from NCBI-Entrez) ..[read more]The protein encoded by this gene is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular traf
A single receptor binds both insulin-like growth factor II and mannose-6-phosphate Science. 1988 et al .
Laureys G, et al. (Genomics. 1988) cloned the IGF2 receptor and showed it to be identical to the cation-independent mannose 6-phosphate receptor (CIM6PR).
Motyka B, et al. (Cell. 2000) reported that Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.
IGF2R - INSULIN-LIKE GROWTH FACTOR 2 RECEPTOR
Family:Other|Scavenger|Mannose
Receptor IGF2R interacts with:
All interactions in Receptor family ( Other|Scavenger|Mannose )
Gene Expression data