Summary: (from NCBI-Entrez) ..[read more]The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2R
IL-15 and IL-2 are two structurally and functionally related cytokines whose high affinity receptors share the IL-2R beta-chain and gamma-chain in association with IL-15R alpha-chain (IL-15R alpha) or IL-2R alpha-chain, respectively (Mortier et al 2004). The 2.8 angstrom crystal structure of IL-2 with the IL2RA was resolved by (Rickert et al. 2005). It revealed that the binding of IL-2R to IL-2 stabilizes a secondary binding site for presentation to IL-2R-beta. Gamma-c is then recruited to the composite surface formed by the IL-2/IL-2R-beta complex.
IL2RA - INTERLEUKIN 2 RECEPTOR, ALPHA
Family:Cytokine1R|IL2RA
Receptor IL2RA interacts with:
All interactions in Receptor family ( Cytokine1R|IL2RA )
Gene Expression data