Summary: (from NCBI-Entrez) ..[read more]The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The
IL-15 and IL-2 are two structurally and functionally related cytokines whose high affinity receptors share the IL-2R beta-chain and gamma-chain in association with IL-15R alpha-chain (IL-15R alpha) or IL-2R alpha-chain, respectively (Mortier et al 2004). The 2.8 angstrom crystal structure of IL-2 with the IL2RA was resolved by (Rickert et al. 2005). It revealed that the binding of IL-2R to IL-2 stabilizes a secondary binding site for presentation to IL-2R-beta. Gamma-c is then recruited to the composite surface formed by the IL-2/IL-2R-beta complex.
IL-15 and IL-2 are two structurally and functionally related cytokines whose high affinity receptors share the IL-2R beta-chain and gamma-chain in association with IL-15R alpha-chain (IL-15R alpha) or IL-2R alpha-chain, respectively. Whereas IL-2 action seems restricted to the adaptative T cells, IL-15 appears to be crucial for the function of the innate immune responses (Mortier et al. 2004).
Receptor IL2RB interacts with:
All interactions in Receptor family ( Cytokine1R|IL-21R )
Gene Expression data