Summary: (from NCBI-Entrez) ..[read more]This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to
The integrin alpha-X-beta-2 has an important role in host defense. Alpha-X-beta-2 functions as a receptor for the complement C3 cleavage product iC3b (Micklem & Sim 1985), fibrinogen [(Loike et al. 1991)&1671533], and ICAM-1 (Diamond et al. 1993).