Protein-protein interaction and not glycosylation determines the binding selectivity of heterodimers between the calcitonin receptor-like receptor and the receptor activity-modifying proteins. J Biol Chem. 2001

McLatchie LM, et al. (Nature, 1998)show that a receptor with seven transmembrane domains, the calcitonin-receptor-like receptor (CRLR), can function as either a CGRP receptor or an adrenomedullin receptor, depending on which members of a new family of single-transmembrane-domain proteins, which we have called receptor-activity-modifying proteins or RAMPs, are expressed.

McLatchie LM, et al. (Nature, 1998) show that a receptor with seven transmembrane domains, the calcitonin-receptor-like receptor (CRLR), can function as either a CGRP receptor or an adrenomedullin receptor, depending on which members of a new family of single-transmembrane-domain proteins, which we have called receptor-activity-modifying proteins or RAMPs, are expressed.

Interaction of calcitonin-gene-related peptide with its receptors. Biochem Soc Trans. 2002 .

Roh J,et al. (J Biol Chem. 2004) revealed that intermedin is a new ligand binding to calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes.