Summary: (from NCBI-Entrez) ..[read more]Neuropeptide Y (NPY; MIM 162640) is one of the most abundant neuropeptides in the mammalian nervous system and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endo
XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors.
Pharmacol Rev. 1998 .
Among the cloned receptors, the Y1, Y2, Y4, and Y5 receptors represent fully defined subtypes, while no functional correlate of the cloned y6 receptor has been reported to date. The subtypes Y1, Y2, and Y5 preferentially bind NPY and PYY, whereas the subtype Y4 preferentially binds PP; the pharmacological profile of the Y6 receptor is controversial (see below). The pharmacologically defined and cloned Y1 and Y2 receptors correspond to each other. Although the cloned Y1 and Y5 receptors can clearly be distinguished by long C-terminal fragments of NPY and PYY (e.g. PYY3-36) and by the antagonist BIBP 3226, their pharmacological profile with regard to NPY, PYY, [Pro34]substituted analogs and short C-terminal fragments (e.g. NPY13-36) is similar .XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors.
Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D, Quirion R, Schwartz T, Westfall T.
Among the cloned receptors, the Y1, Y2, Y4, and Y5 receptors represent fully defined subtypes, while no functional correlate of the cloned y6 receptor has been reported to date. The subtypes Y1, Y2, and Y5 preferentially bind NPY and PYY, whereas the subtype Y4 preferentially binds PP; the pharmacological profile of the Y6 receptor is controversial (see below). The pharmacologically defined and cloned Y1 and Y2 receptors correspond to each other. Although the cloned Y1 and Y5 receptors can clearly be distinguished by long C-terminal fragments of NPY and PYY (e.g. PYY3-36) and by the antagonist BIBP 3226, their pharmacological profile with regard to NPY, PYY, [Pro34]substituted analogs and short C-terminal fragments (e.g. NPY13-36) is similar .XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors.
Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D, Quirion R, Schwartz T, Westfall T.
NPY1R - NEUROPEPTIDE Y RECEPTOR Y1
Family:7TM|A|Polypeptide|NeuropeptideY_tachykinin_orexin_pancreatic_peptide
Receptor NPY1R interacts with:
All interactions in Receptor family ( 7TM|A|Polypeptide|NeuropeptideY_tachykinin_orexin_pancreatic_peptide )
Gene Expression data