Synonyms:DIABETES INSIPIDUS, NEPHROGENIC, TYPE I, NDI|ARGININE VASOPRESSIN RECEPTOR 2, INCLUDED, AVPR2, INCLUDED|ANTIDIURETIC HORMONE RECEPTOR, INCLUDED, ADHR, INCLUDED|VASOPRESSIN V2 RECEPTOR, INCLUDED, V2R, INCLUDED
External
links:Entrez Gene, Omim
Summary: (from NCBI-Entrez) ..[read more]This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that incl
AVP receptors are classified into at least 3 subtypes: V1a, V1b, and V2. The V1a receptor (600821) has been localized in the liver, vascular smooth muscle, brain, mesangial cells, and platelets. The V2 receptor (304800) is exclusively expressed in the kidney, and defects in this receptor result in nephrogenic diabetes insipidus. Sugimoto et al. (1994) cloned the V1b receptor from a cDNA library of human pituitary. (The gene is also referred to as AVPR3.)