Summary: (from NCBI-Entrez) ..[read more]This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal do
Rajagopalan et al. (2004) presented evidence that neogenin functions as a receptor for repulsive guidance molecule (RGM). Like Rgm, neogenin was expressed in a gradient across the embryonic chicken retina. The avoidance of Rgm by chicken temporal retinal axons was blocked by anti-neogenin antibody and the soluble neogenin ectodomain. Dorsal root ganglion axons were unresponsive to Rgm, but were converted to a responsive state by neogenin expression.
Netrin-3 and its receptor, neogenin stimulate myotube formation and enhance myogenic bHLH- and NFAT-dependent transcription. Neogenin and CDO form a complex, and CDO modulates netrin signaling. (Kang et al. 2004).
Receptor NEO1 interacts with:
All interactions in Receptor family ( Netrin|DCC Receptors )
Gene Expression data