Summary: (from NCBI-Entrez) ..[read more]The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for
GDNF family ligands signal through receptor complex consisting of a glycosylphosphatidylinositol-linked GDNF family receptor (GFR) alpha subunit and the transmembrane receptor tyrosine kinase RET . Human GDNF receptor alpha-4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells (Lindahl et al. 2001).
Receptor GFRA4 interacts with:
All interactions in Receptor family ( GPI-anchored )
Gene Expression data