Summary: (from NCBI-Entrez) ..[read more]The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and func
MD-2, a glycoprotein that is essential for the innate response to lipopolysaccharide (LPS), binds to both LPS and the extracellular domain of Toll-like receptor 4 (TLR4) (Kennedy et al. 2004). MD-2.LPS complex, but not LPS alone, induces epithelial cells, which express TLR4 but not MD-2, to secrete interleukin-6 and interleukin-8.
TLR4 - TOLL-LIKE RECEPTOR 4 PRECURSOR
Family:Toll|TIL
All interactions in Receptor family ( Toll|TIL )
Gene Expression data