Canalis E, et al. (Endocr Rev. 2003)discussed the BMPs and their receptors in the latest rewiew. BMP-2 and BMP-4 are 92% identical in their amino acid sequence. They both bind to type IA and IB receptors.

ten Dijke P,et al. (J Biol Chem. 1994) firstly reported that BMP-4 bound to ALK-3 and ALK-6 efficiently and their results suggest that ALK-3 and ALK-6 are type I receptors for BMP-4.

Galloway SM, et al. (Mol Cell Endocrinol. 2002) believed that BMP1B receptor is responsible for BMP15 signaling trnasduction.

The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb. Development. 2000 .

Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5 (Nishitoh et al. 1996).

Modulation of GDF5/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2. Ror2 and BRI-b associate in the presence and absence of GDF5 (Sammar et al. 2004).