Summary: (from NCBI-Entrez) ..[read more]This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, i
Plexin-A3 and -A4 together mediate the responses to class 3 Semaphorins in sensory and sympathetic neurons, with Plexin-A4 being principally responsible for mediating responses to Sema3A via Neuropilin-1 and Plexin-A3 being principally responsible for responses to Sema3F via Neuropilin-2 (Yaron et al. 2005).
Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4).
Proc Natl Acad Sci U S A. 1998