Summary: (from NCBI-Entrez) ..[read more]This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as rep
The attractive responses of Xenopus spinal axons to netrin-1, which are mediated by DCC are converted to repulsion by expression of UNC5. (Hong et al. 1999) found that netrin-1 triggers the formation of a receptor complex of DCC and UNC5 which derepresses the interaction between their cytoplasmic domains, thereby converting DCC-mediated attraction to UNC5/DCC-mediated repulsion
Receptor UNC5C interacts with:
All interactions in Receptor family ( Netrin|Netrin2 )
Gene Expression data