Carlin CR and Knowles BB. (Proc Natl Acad Sci U S A. 1982) presented evidence that SA-7 is the human receptor for epidermal growth factor (EGF).

Ignotz RA,et al.(Proc Natl Acad Sci U S A. 1986) demonstrated that This TGF-alpha precursor binds to epidermal growth factor/TGF-alpha receptors and activates the receptor-associated tyrosine kinase activity in intact cells.

Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities J Biol Chem. 1996 . Epiregulin bound to the EGF receptors of epidermoid carcinoma A431 cells much more weakly than did EGF, but was nevertheless much more potent than EGF as a mitogen for rat primary hepatocytes and Balb/c 3T3 A31 fibroblasts. These findings suggest that epiregulin plays important roles in regulating the growth of epithelial cells and fibroblasts by binding to receptors for EGF-related ligands Toyoda H, et al. 1995.

Shoyab M, et al. (Science, 1989)studied the Structure and function of human amphiregulin abd found that amphiregulin is a member of EGF family. It binds to and activates EGF receptor.

Watanabe T, et al. (J. Biol. Chem. 1994) studied the molecular structure, biological activities, and receptor interaction and found that BTC can bind EGF receptor with the same affinity as EGF.

The chemical synthesis and binding affinity to the EGF receptor of the EGF-like domain of heparin-binding EGF-like growth factor (HB-EGF). Shin SY et al. .. indicates that the two N-terminal residues of the EGF-like domain of HB-EGF are necessary for its optimal binding affinity to the EGF receptor.

EGF receptor modifies cellular responses to hyaluronan in glioblastoma cell lines. Tsatas D et al. Cell contact with the extracellular matrix component, hyaluronan, plays a pivotal role in glioma cell invasion and proliferation. Although it is well established that glioma cells can bind hyaluronan to their surface via the expression of CD44, the cellular responses following ligand-receptor interaction remain poorly understood. ... Here we present evidence that CD44 co-immunoprecipitates with EGFR and ErbB2 in the glioma cell lines U87MG and SMA560. ... These results indicate a novel functional relationship between CD44 and EGFR in glioma cell lines. ... These findings provide new insights into the mode by which hyaluronan regulates the malignant phenotype and also suggest a role for EGFR-CD44 interactions in glial tumorigenesis.