Syndecan 2 proteoglycan interacts with the C-terminal heparin-binding domain of fibronectin at the highly sulfated cluster(s), to result in the induction of stress fiber formation in cooperation with integrin alpha-5-beta-1 (Kusano et al. 2000).

The two molecules appear to have a ligand-receptor relationship mediated by the alpha(5)beta(1) ligand binding pocket (Bax et al. 2004).

Zhang et al. (1998) found that the recombinant MDC-15 disintegrin-like domain of ADAM-15 specifically interacts with alpha-v-beta-3 but not with the other integrins. These finding were supported also by (Nath et al. 1999)

Zhang et al. (1998) found that the recombinant MDC-15 disintegrin-like domain of ADAM-15 specifically interacts with alpha-v-beta-3 but not with the other integrins. These finding were supported also by (Nath et al. 1999).

In MOLT-4 cells, the integrin alpha-5-beta-1 contributes to cell binding through the disintegrin domain of metargidin (called also ADAM-15)(Nath et al. 1999).

Recombinant ADAM 23 promotes attachment of different human cells of neural origin, such as neuroblastoma cells. Analysis of ADAM 23 binding to integrins revealed a specific interaction with alphavbeta3, mediated by a short amino acid sequence present in its putative disintegrin loop (Cal et al. 2000).

Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3. J Biol Chem. 1998 .

Distinct ligand-binding modes for integrin alpha-5-beta-3-mediated adhesion to fibronectin versus vitronectin (Boettiger et al. 2001).

Characterization of the integrin alpha-5-beta-6 as a fibronectin-binding protein Busk et al. 1992).

Integrin alpha(v)beta(3)/vitronectin interaction affects expression of the urokinase system in human ovarian cancer cells (Hapke et al. 2001).

Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins. Proc Natl Acad Sci U S A. 2003 .