Summary: (from NCBI-Entrez) ..[read more]This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines
Li X, et al. (Nat Cell Biol. 2000) identified that PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.The four dimeric isoforms, PDGF-AA, PDGFAB, PDGF-BB and PDGF-CC can bind to and active PDGFRα (Fredriksson et al. 2004).