Summary: (from NCBI-Entrez) ..[read more]This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracell
Chang et al. (1989)cloned a second human natriuretic peptide-receptor guanylate cyclase, the ANP-B receptor. The ANP-B receptor is preferentially activated by porcine brain natriuretic peptide rather than human alpha-ANP, whereas the ANP-A receptor responds similarly to both natriuretic peptides.
Tremblay J, et al. (Mol Cell Biochem. 2002) extensively discussed the biochemistry and physiology of the natriuretic peptide receptor guanylyl cyclases. In this paper the authors reviewed that GC-B is the main receptor for CNP, the latter having a more paracrine role at the vascular and venous levels.
Receptor NPR2 interacts with:
All interactions in Receptor family ( GuaCyc )
Gene Expression data