Bellosta P., et al. (Mol Cell Biol, 2001) identified the receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis, found FGF4 can bind and activate all FGF receptor members, FGFR1, FGFR2, FGFR3 and FGF4.

Bellosta P., et al. (Mol Cell Biol, 2001) identified the receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis, found FGF8 can bind and activate FGFR3 and FGF4.

Ornitz DM, et al. (J Biol Chem. 1996) carried out a series of experiments and figured out the pairship of fibroblast growth factor family and their receptors.

Ornitz DM, et al. (J Biol Chem. 1996) carried out a series of experiments and figured out the pairship of fibroblast growth factor family and their receptors.

FGF19, one of the most divergent human FGFs, is unique in binding solely to one receptor, FGFR4. A model for the complex of FGF19 with FGFR4 demonstrates that unique sequences in both FGF19 and FGFR4 are key to the formation of the complex (Harmer et al. 2004).

Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23. Yu X, et al FGF23 binds and activates the c splice isoforms of FGFR1-3, as well as FGFR4, but not the b splice isoforms of FGFR1-3.

Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction. EMBO J. 1992