Summary: (from NCBI-Entrez) ..[read more]Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to
Pasquale EB.(Curr Opin Cell Biol. 1997)reviewed the Eph family of receptors and their individual ligands. EphB2 can bind to Ephrins -B1 to B3, but it binds to Ephrin-B1 with the highest affinity compared with the other two ligands.
The EphA receptors are generally thought to become activated by ephrin-A ligands, whereas the EphB receptors interact with ephrin-B ligands. But Himanen JP, et al. (Nat Neurosci. 2004) reported that ephrin-A ligand Efna5 in fact binds to class B receptor Ephb2 with high affinity. Exposure of EphB2-expressing cells to ephrin-A5 leads to receptor clustering, autophosphorylation and initiation of downstream signaling. Ephrin-A5 induces EphB2-mediated growth cone collapse and neurite retraction in a model system. We further show, using X-ray crystallography, that the ephrin-A5-EphB2 complex is a heterodimer and is architecturally distinct from the tetrameric EphB2-ephrin-B2 structure.
Receptor EPHB2 interacts with:
All interactions in Receptor family ( RTK|EPHRIN )
Gene Expression data