Summary: (from NCBI-Entrez) ..[read more]The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, AC
Canalis E, et al. (Endocr Rev. 2003) discussed the BMPs and their receptors in the latest rewiew. BMP-2 and BMP-4 are 92% identical in their amino acid sequence. They both bind to type IA and IB receptors.
ten Dijke P,et al. (J Biol Chem. 1994) firstly reported that BMP-4 bound to ALK-3 and ALK-6 efficiently and their results suggest that ALK-3 and ALK-6 are type I receptors for BMP-4.
Miyazono K & Miyazawa K. (Sci STKE. 2002) discussed the BMP signaling: BMP-6 and BMP-7 different from BMP-2 and -4, they bind to type I receptors ALK-2, ALK-3 and ALK-6.
Miyazono K & Miyazawa K. (Sci STKE. 2002) discussed the BMP signaling: BMP-6 and BMP-7 different from BMP-2 and -4, they bind to type I receptors ALK-2, ALK-3 and ALK-6.
Ligand GDF6 - GROWTH DIFFERENTIATION FACTOR 6andReceptor BMPR2 - BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE I ...[read more..]
Identification of receptors and signaling pathways for orphan BMP/GDF ligands based on genomic analyses.
J Biol Chem. 2005 .
Ligand BMP10 - BONE MORPHOGENETIC PROTEIN 10andReceptor BMPR2 - BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE I ...andReceptor ACVR2A - ACTIVIN RECEPTOR TYPE II PRECURSOR[read more..]
Identification of receptors and signaling pathways for orphan BMP/GDF ligands based on genomic analyses.
J Biol Chem. 2005 .
Ligand GDF7 - GROWTH DIFFERENTIATION FACTOR 7andReceptor BMPR2 - BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE I ...andReceptor ACVR2A - ACTIVIN RECEPTOR TYPE II PRECURSOR[read more..]
Identification of receptors and signaling pathways for orphan BMP/GDF ligands based on genomic analyses.
J Biol Chem. 2005 .