Lindsell CE, et al. (Cell, 1995) isolated a rat cDNA clone, Jagged, which was showed to encode a ligand for vertebrate Notch1.

Shimizu K, et al. reported that Delta1, Jagged1, and Jagged2 are ligands for Notch1 and Notch3 receptors.

In vertebrates, members of a novel family of genes which encode small secretory proteins, CCN, were demonstrated to bind to Notch and stimulate signaling (Katsube & Sakamoto). This is not a ligand type binding, but rather a modifier of the protein structure of Notch, so as to form a macromolecular complex.

Delta-1 activation of notch-1 signaling results in HES-1 transactivation (Jarriault et al. 1998).

Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood. 2006