Summary: (from NCBI-Entrez) ..[read more]This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically ha
Pasquale EB.(Curr Opin Cell Biol. 1997) presented a review to characterize the Eph family of receptors. In this review, the author stated that Ephrin-A5 has the highest affinity to EphA4 among all the ligands.
Local circuits in the spinal cord that generate locomotion are termed central pattern generators (CPGs). These provide coordinated bilateral control over the normal limb alternation that underlies walking. The molecules that organize the mammalian CPG are unknown. Isolated spinal cords from mice lacking either the EphA4 receptor or its ligand ephrinB3 have lost left-right limb alternation and instead exhibit synchrony. We identified EphA4-positive neurons as an excitatory component of the locomotor CPG. Our study shows that dramatic locomotor changes can occur as a consequence of local genetic rewiring and identifies genes required for the development of normal locomotor behavior (Kullander et al. 2003.
Receptor EPHA4 interacts with:
All interactions in Receptor family ( RTK|EPHRIN )
Gene Expression data