D'Arcangelo G, et al. (Neuron. 1999) found that reelin is a ligand for lipoprotein receptors. After binding to VLDLR on the cell surface, Reelin is internalized into vesicles. In dissociated neurons, apoE reduces the level of Reelin-induced tyrosine phosphorylation of Dab1.

The VLDL receptor binds apolipoprotein E but not apo B, and is expressed in fatty acid active tissues (heart, muscle, adipose) and macrophages abundantly (Takahashi et al. 2003)

Tissue factor pathway inhibitor inhibits endothelial cell proliferation via association with the very low density lipoprotein receptor (Hembrough et al. 2001).