Synonyms:IL1 receptor-related protein
External
links:Entrez Gene, Omim
Summary: (from NCBI-Entrez) ..[read more]The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to i
Interleukin (IL)-18 was identified as a molecule that induces IFN-gamma production and enhances NK cell cytotoxicity.Torigoe K, et al.(J Biol Chem. 1997) purified a receptor and found this receptor is the best binder for IL-18. IL-1R related protein 1 (IL-1Rrp1, also designated IL-18 receptor) and IL-1R accessory protein-like (IL-1RAcPL) confer responsiveness to IL-18 in a highly specific (no response to other IL-1 ligands) and unique manner (no functional pairing with other IL-1Rs and IL-1R-like molecules) (Debets et al. 2000).
Receptor IL18R1 interacts with:
All interactions in Receptor family ( Cytokine1R|IL-1RL2 )
Gene Expression data