Summary: (from NCBI-Entrez) ..[read more]This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphori
Usui et al. (2003) found in yeast two-hybrid screening that an intracellular 349 amino acid fragment of plexin-B1 is interacting with plexin-A1. Furthermore, in a mammalian expression system Plexin-B1 physically associated with plexin-A1, but not with plexin-A2 or A3. They proposed that plexin-A1 and B1 interact in the adult brain and transduce Sema3A signaling in cooperation.
Neuropilin (NP)-1 and -2 bind to class 3 semaphorins with high affinities and are necessary for Sema3A-mediated repulsive guidance events (Nakamura et al. 2000. (Raper 2000)undefined
Neuropilin (NP)-1 and -2 bind to class 3 semaphorins with high affinities and are necessary for Sema3A-mediated repulsive guidance events (Nakamura et al. 2000. (Raper 2000)undefined
Receptor PLXNA2 interacts with:
All interactions in Receptor family ( Plexins )
Gene Expression data