Summary: (from NCBI-Entrez) ..[read more]The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and rec
Interleukin-12 is a heterodimeric cytokine that is composed of a disulfide-bonded 40-kDa subunit (IL-12B) and a 35-kDa subunit (IL-12A). IL-12R beta 1 is the subunit primarily responsible for binding IL-12, whereas IL-12R beta 2 plays an essential role in mediating the biological functions of IL-12 (Wu et al. 2000).
Receptor IL12RB2 interacts with:
All interactions in Receptor family ( Cytokine1R|OSMR )
Gene Expression data