Summary: (from NCBI-Entrez) ..[read more]This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in
An S, et al. (J Biol Chem. 1998) cloned a cDNA coding a G protein-coupled receptor, designated Edg4. The Edg4 protein is 46% identical and 72% similar in amino acid sequence to human Edg2. When overexpressed in Jurkat T cells, the Edg4 protein mediated LPA-induced activation of a serum response element reporter gene with LPA concentration dependence (EC50 of 10 nM) and specificity. Therefore, EDG4 is also regards as a receptor for lysophosphatidic acid (LPA), produced by phosphatidic acid-selective phospholipase A1.
EDG4 - LYSOPHOSPHATIDIC ACID RECEPTOR EDG-4
Family:7TM|A|Lipid|Lysosphingolipid/lysophosphatidic_acid/EDG
Receptor EDG4 interacts with:
All interactions in Receptor family ( 7TM|A|Lipid|Lysosphingolipid/lysophosphatidic_acid/EDG )
Gene Expression data