ul_10005----
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PPBD protein
Gene name LCK
Synonyms LCK
GO annotations GO_component: lipid raft [PMID 12732664]; pericentriolar material [PMID 7513706]; plasma membrane [PMID 15489916]
GO_function:ATP binding; ATPase binding [PMID 15671290]; CD4 receptor binding [PMID 7486703]; CD8 receptor binding [PMID 2470098]; glycoprotein binding [PMID 7513706] [PMID 14625311] [PMID 15554700]; nucleotide binding; phosphoinositide 3-kinase binding [PMID 7504174]; protein C-terminus binding [PMID 16245368]; protein kinase binding [PMID 8618896]; protein serine/threonine phosphatase activity [PMID 8506364]; protein-tyrosine kinase activity [PMID 214242]; SH2 domain binding [PMID 7852312] [PMID 8794306]; transferase activity
GO_process: caspase activation [PMID 16116473]; hemopoiesis [PMID 12884910]; induction of apoptosis [PMID 16116473]; intracellular signaling cascade [PMID 10358157]; positive regulation of T cell activation [PMID 8943371]; positive regulation of T cell receptor signaling pathway [PMID 12614355]; protein amino acid phosphorylation [PMID 3265417]; Ras protein signal transduction [PMID 10799545]; regulation of lymphocyte activation [PMID 7852312]; regulation of progression through cell cycle [PMID 8139546]; release of sequestered calcium ion into cytosol; response to drug [PMID 16116473]; T cell differentiation [PMID 1579166]; zinc ion homeostasis [PMID 11739864]
RefSeq accession NP_001036236
SwissProt accession
Substrate protein
Gene name vav1
Synonyms vav1
GO annotations GO_component: intracellular; nucleus
GO_function:diacylglycerol binding; metal ion binding; protein binding [PMID 10394361]; Rho guanyl-nucleotide exchange factor activity; transcription factor activity [PMID 2477241]; zinc ion binding
GO_process: intracellular signaling cascade; regulation of Rho protein signal transduction
RefSeq accession NP_005419
SwissProt accession
Sequence:(RefSeq accession:NP_005419; substrate region highlighted if known)
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MELWRQCTHW LIQCRVLPPS HRVTWDGAQV CELAQALRDG VLLCQLLNNL LPHAINLREV
NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF DVQDFGKVIY TLSALSWTPI
AQNRGIMPFP TEEESVGDED IYSGLSDQID DTVEEDEDLY DCVENEEAEG DEIYEDLMRS
EPVSMPPKMT EYDKRCCCLR EIQQTEEKYT DTLGSIQQHF LKPLQRFLKP QDIEIIFINI
EDLLRVHTHF LKEMKEALGT PGAANLYQVF IKYKERFLVY GRYCSQVESA SKHLDRVAAA
REDVQMKLEE CSQRANNGRF TLRDLLMVPM QRVLKYHLLL QELVKHTQEA MEKENLRLAL
DAMRDLAQCV NEVKRDNETL RQITNFQLSI ENLDQSLAHY GRPKIDGELK ITSVERRSKM
DRYAFLLDKA LLICKRRGDS YDLKDFVNLH SFQVRDDSSG DRDNKKWSHM FLLIEDQGAQ
GYELFFKTRE LKKKWMEQFE MAISNIYPEN ATANGHDFQM FSFEETTSCK ACQMLLRGTF
YQGYRCHRCR ASAHKECLGR VPPCGRHGQD FPGTMKKDKL HRRAQDKKRN ELGLPKMEVF
QEYYGLPPPP GAIGPFLRLN PGDIVELTKA EAEQNWWEGR NTSTNEIGWF PCNRVKPYVH
GPPQDLSVHL WYAGPMERAG AESILANRSD GTFLVRQRVK DAAEFAISIK YNVEVKHIKI
MTAEGLYRIT EKKAFRGLTE LVEFYQQNSL KDCFKSLDTT LQFPFKEPEK RTISRPAVGS
TKYFGTAKAR YDFCARDRSE LSLKEGDIIK ILNKKGQQGW WRGEIYGRVG WFPANYVEED
YSEYC
Records:
Category Evidence Reference
A Inference , , [17050525]
End of Record Details