ul_10035----
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PPBD protein
Gene name GRB2
Synonyms GRB2
GO annotations GO_component: cytosol [PMID 14722116]
GO_function:epidermal growth factor receptor binding [PMID 12577067]; insulin receptor substrate binding [PMID 8388384]; SH3/SH2 adaptor activity [PMID 8253073]
GO_process: cell-cell signaling [PMID 8253073]; epidermal growth factor receptor signaling pathway [PMID 1322798]; insulin receptor signaling pathway [PMID 8388384]; intracellular signaling cascade; Ras protein signal transduction [PMID 8253073]
RefSeq accession NP_987102
SwissProt accession
Substrate protein
Gene name TGFBR2
Synonyms TBETAR-II
GO annotations GO_component: integral to membrane; membrane
GO_function:ATP binding; magnesium ion binding; manganese ion binding; nucleotide binding; protein binding [PMID 8242742]; receptor activity; transferase activity; transforming growth factor beta receptor activity, type II [PMID 7761852]
GO_process: positive regulation of cell proliferation [PMID 7761852]; protein amino acid dephosphorylation; protein amino acid phosphorylation; transmembrane receptor protein serine/threonine kinase signaling pathway
RefSeq accession NP_001020018
SwissProt accession
Sequence:(RefSeq accession:NP_001020018; substrate region highlighted if known)
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MGRGLLRGLW PLHIVLWTRI ASTIPPHVQK SDVEMEAQKD EIICPSCNRT AHPLRHINND
MIVTDNNGAV KFPQLCKFCD VRFSTCDNQK SCMSNCSITS ICEKPQEVCV AVWRKNDENI
TLETVCHDPK LPYHDFILED AASPKCIMKE KKKPGETFFM CSCSSDECND NIIFSEEYNT
SNPDLLLVIF QVTGISLLPP LGVAISVIII FYCYRVNRQQ KLSSTWETGK TRKLMEFSEH
CAIILEDDRS DISSTCANNI NHNTELLPIE LDTLVGKGRF AEVYKAKLKQ NTSEQFETVA
VKIFPYEEYA SWKTEKDIFS DINLKHENIL QFLTAEERKT ELGKQYWLIT AFHAKGNLQE
YLTRHVISWE DLRKLGSSLA RGIAHLHSDH TPCGRPKMPI VHRDLKSSNI LVKNDLTCCL
CDFGLSLRLD PTLSVDDLAN SGQVGTARYM APEVLESRMN LENVESFKQT DVYSMALVLW
EMTSRCNAVG EVKDYEPPFG SKVREHPCVE SMKDNVLRDR GRPEIPSFWL NHQGIQMVCE
TLTECWDHDP EARLTAQCVA ERFSELEHLD RLSGRSCSEE KIPEDGSLNT TK
Records:
Category Evidence Reference
A Mutagenesis , , [17440088]
End of Record Details