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PPBD protein
Gene name YWHAB( Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide. )
Synonyms GW128; HS1; KCIP-1; Protein 1054; Protein kinase C inhibitor protein 1
GO annotations GO_component: cytoplasm [PMID 12963375]; perinuclear region [PMID 12963375]
GO_function:monooxygenase activity; protein domain specific binding
GO_process:
RefSeq accession NP_003395
SwissProt accession P31946
Substrate protein
Gene name IGF1R( Description: insulin-like growth factor 1 receptor. )
Synonyms CD221; CD221 antigen; EC 2.7.10.1; IGF-I receptor; IGFIR; Insulin-like growth factor I receptor; JTK13; MGC142170; MGC142172; MGC18216
GO annotations GO_component: integral to plasma membrane [PMID 7679099]; membrane
GO_function:ATP binding; epidermal growth factor receptor activity; insulin receptor substrate binding [PMID 7541045]; insulin-like growth factor binding [PMID 1846292] [PMID 7679099]; insulin-like growth factor receptor activity [PMID 7679099]; nucleotide binding; phosphoinositide 3-kinase binding [PMID 7541045]; receptor activity; transferase activity
GO_process: anti-apoptosis [PMID 8710868]; insulin receptor signaling pathway [PMID 10829031]; insulin-like growth factor receptor signaling pathway [PMID 7679099]; positive regulation of cell proliferation [PMID 10749889]; protein amino acid autophosphorylation [PMID 1846292] [PMID 7679099] [PMID 11162456]; protein tetramerization [PMID 1846292]; regulation of progression through cell cycle [PMID 3003744]; signal transduction [PMID 3003744]
RefSeq accession NP_000866
SwissProt accession P08069
GO Pathway:
GO:0048009     insulin-like growth factor receptor signaling pathway
GO:0000074     regulation of progression through cell cycle
Sequence:(RefSeq accession:NP_000866; substrate region highlighted if known)
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MKSGSGGGSP TSLWGLLFLS AALSLWPTSG EICGPGIDIR NDYQQLKRLE NCTVIEGYLH
ILLISKAEDY RSYRFPKLTV ITEYLLLFRV AGLESLGDLF PNLTVIRGWK LFYNYALVIF
EMTNLKDIGL YNLRNITRGA IRIEKNADLC YLSTVDWSLI LDAVSNNYIV GNKPPKECGD
LCPGTMEEKP MCEKTTINNE YNYRCWTTNR CQKMCPSTCG KRACTENNEC CHPECLGSCS
APDNDTACVA CRHYYYAGVC VPACPPNTYR FEGWRCVDRD FCANILSAES SDSEGFVIHD
GECMQECPSG FIRNGSQSMY CIPCEGPCPK VCEEEKKTKT IDSVTSAQML QGCTIFKGNL
LINIRRGNNI ASELENFMGL IEVVTGYVKI RHSHALVSLS FLKNLRLILG EEQLEGNYSF
YVLDNQNLQQ LWDWDHRNLT IKAGKMYFAF NPKLCVSEIY RMEEVTGTKG RQSKGDINTR
NNGERASCES DVLHFTSTTT SKNRIIITWH RYRPPDYRDL ISFTVYYKEA PFKNVTEYDG
QDACGSNSWN MVDVDLPPNK DVEPGILLHG LKPWTQYAVY VKAVTLTMVE NDHIRGAKSE
ILYIRTNASV PSIPLDVLSA SNSSSQLIVK WNPPSLPNGN LSYYIVRWQR QPQDGYLYRH
NYCSKDKIPI RKYADGTIDI EEVTENPKTE VCGGEKGPCC ACPKTEAEKQ AEKEEAEYRK
VFENFLHNSI FVPRPERKRR DVMQVANTTM SSRSRNTTAA DTYNITDPEE LETEYPFFES
RVDNKERTVI SNLRPFTLYR IDIHSCNHEA EKLGCSASNF VFARTMPAEG ADDIPGPVTW
EPRPENSIFL KWPEPENPNG LILMYEIKYG SQVEDQRECV SRQEYRKYGG AKLNRLNPGN
YTARIQATSL SGNGSWTDPV FFYVQAKTGY ENFIHLIIAL PVAVLLIVGG LVIMLYVFHR
KRNNSRLGNG VLYASVNPEY FSAADVYVPD EWEVAREKIT MSRELGQGSF GMVYEGVAKG
VVKDEPETRV AIKTVNEAAS MRERIEFLNE ASVMKEFNCH HVVRLLGVVS QGQPTLVIME
LMTRGDLKSY LRSLRPEMEN NPVLAPPSLS KMIQMAGEIA DGMAYLNANK FVHRDLAARN
CMVAEDFTVK IGDFGMTRDI YETDYYRKGG KGLLPVRWMS PESLKDGVFT TYSDVWSFGV
VLWEIATLAE QPYQGLSNEQ VLRFVMEGGL LDKPDNCPDM LFELMRMCWQ YNPKMRPSFL
EIISSIKEEM EPGFREVSFY YSEENKLPEP EELDLEPENM ESVPLDPSAS SSSLPLPDRH
SGHKAENGPG PGVLVLRASF DERQPYAHMN GGRKNERALP LPQSSTC
Records:
Category Evidence Reference
A Peptide library Furlanetto RW, Dey BR, Lopaczynski W, Nissley SP., 14-3-3 proteins interact with the insulin-like growth factor receptor but not the insulin receptor., [9581554]
A Inference Parvaresch S, Yesilkaya T, Baer K, Al-Hasani H, Klein HW., 14-3-3 binding to the IGF-1 receptor is mediated by serine autophosphorylation., [12482592]
End of Record Details