ul_11----
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PPBD protein
Gene name SFN( Description: stratifin. )
Synonyms Epithelial cell marker protein 1; Stratifin; YWHAS
GO annotations GO_component: cytoplasm [PMID 10767298]; extracellular space [PMID 8515476]
GO_function:protein domain specific binding; protein kinase C inhibitor activity [PMID 8515476]
GO_process: cell proliferation [PMID 10767298]; negative regulation of protein kinase activity [PMID 8515476]; regulation of progression through cell cycle [PMID 10767298]; signal transduction [PMID 8515476]
RefSeq accession NP_006133
SwissProt accession P31947
Substrate protein
Gene name TP53( Description: tumor protein p53 (Li-Fraumeni syndrome). )
Synonyms Antigen NY-CO-13; LFS1; Phosphoprotein p53; TRP53; Tumor suppressor p53; p53
GO annotations GO_component: cytoplasm [PMID 7720704]; insoluble fraction [PMID 12915590]; mitochondrion [PMID 12667443]; nuclear matrix [PMID 11080164]; nucleolus [PMID 12080348]; nucleoplasm [PMID 11080164] [PMID 12915590]; nucleus [PMID 7720704]
GO_function:ATP binding [PMID 8183576]; copper ion binding [PMID 7824276]; DNA strand annealing activity [PMID 8183576]; enzyme binding [PMID 10666337] [PMID 15577914]; metal ion binding; nuclease activity [PMID 11002423]; protein binding [PMID 15782130]; protein heterodimerization activity [PMID 10837489]; protein N-terminus binding [PMID 11861836]; transcription factor activity [PMID 7587074]; zinc ion binding [PMID 10065153]
GO_process: apoptosis [PMID 7720704]; base-excision repair [PMID 15116721]; caspase activation via cytochrome c [PMID 12667443]; cell aging [PMID 12080348]; cell cycle; cell cycle arrest [PMID 8675009]; cell differentiation [PMID 10065150]; cell proliferation [PMID 10065150]; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis [PMID 14654789]; negative regulation of cell growth [PMID 8986812]; negative regulation of helicase activity [PMID 7663514]; nucleotide-excision repair [PMID 7663514]; protein complex assembly [PMID 12915590]; protein tetramerization [PMID 15116721]; regulation of mitochondrial membrane permeability [PMID 15116721]; regulation of transcription, DNA-dependent [PMID 7587074]; response to DNA damage stimulus [PMID 8986812]; transcription
RefSeq accession NP_000537
SwissProt accession P04637
Sequence:(RefSeq accession:NP_000537; substrate region highlighted if known)
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MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI EQWFTEDPGP
DEAPRMPEAA PRVAPAPAAP TPAAPAPAPS WPLSSSVPSQ KTYQGSYGFR LGFLHSGTAK
SVTCTYSPAL NKMFCQLAKT CPVQLWVDST PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE
RCSDSDGLAP PQHLIRVEGN LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS
SCMGGMNRRP ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP
PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QIRGRERFEM FRELNEALEL KDAQAGKEPG
GSRAHSSHLK SKKGQSTSRH KKLMFKTEGP DSD
Records:
Category Evidence Reference
A Inference Waterman MJ, Stavridi ES, Waterman JL, Halazonetis TD., ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins., [9620776]
A Inference Satyamoorthy K, Chehab NH, Waterman MJ, Lien MC, El-Deiry WS, Herlyn M, Halazonetis TD., Aberrant regulation and function of wild-type p53 in radioresistant melanoma cells., [11007451]
End of Record Details