ul_1380----
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PPBD protein
Gene name MDC1( Description: mediator of DNA damage checkpoint 1. )
Synonyms DKFZp781A0122; KIAA0170; NFBD1
GO annotations GO_component: intracellular; nucleus [PMID 15604234]
GO_function:protein binding [PMID 12607005]
GO_process: cell cycle; DNA repair
RefSeq accession NP_055456
SwissProt accession Q14676
Substrate protein
Gene name CHEK2( Description: CHK2 checkpoint homolog (S. pombe). )
Synonyms CDS1; CHK2; Cds1; EC 2.7.11.1; HuCds1; LFS2; PP1425; RAD53
GO annotations GO_component: nucleus
GO_function:ATP binding; magnesium ion binding; nucleotide binding; protein binding [PMID 12402044]; protein serine/threonine kinase activity [PMID 9836640]; transferase activity
GO_process: cell cycle; DNA damage checkpoint [PMID 9889122] [PMID 10617473]; protein amino acid phosphorylation; response to DNA damage stimulus [PMID 9836640] [PMID 9889122]
RefSeq accession NP_009125
SwissProt accession O96017
GO Pathway:
GO:0008630     DNA damage response, signal transduction resulting in induction of apoptosis
Sequence:(RefSeq accession:NP_009125; substrate region highlighted if known)
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MSRESDVEAQ QSHGSSACSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL
SSLETVSTQE LYSIPEDQEP EDQEPEEPTP APWARLWALQ DGFANLECVN DNYWFGRDKS
CEYCFDEPLL KRTDKYRTYS KKHFRIFREV GPKNSYIAYI EDHSGNGTFV NTELVGKGKR
RPLNNNSEIA LSLSRNKVFV FFDLTVDDQS VYPKALRDEY IMSKTLGSGA CGEVKLAFER
KTCKKVAIKI ISKRKFAIGS AREADPALNV ETEIEILKKL NHPCIIKIKN FFDAEDYYIV
LELMEGGELF DKVVGNKRLK EATCKLYFYQ MLLAVQYLHE NGIIHRDLKP ENVLLSSQEE
DCLIKITDFG HSKILGETSL MRTLCGTPTY LAPEVLVSVG TAGYNRAVDC WSLGVILFIC
LSGYPPFSEH RTQVSLKDQI TSGKYNFIPE VWAEVSEKAL DLVKKLLVVD PKARFTTEEA
LRHPWLQDED MKRKFQDLLS EENESTALPQ VLAQPSTSRK RPREGEAEGA ETTKRPAVCA
AVL
Records:
Category Evidence Reference
A Peptide library Lou Z, Minter-Dykhouse K, Wu X, Chen J., MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways., [12607004]
End of Record Details