ul_15----
Record details: Hide
PPBD protein
Gene name SFN( Description: stratifin. )
Synonyms Epithelial cell marker protein 1; Stratifin; YWHAS
GO annotations GO_component: cytoplasm [PMID 10767298]; extracellular space [PMID 8515476]
GO_function:protein domain specific binding; protein kinase C inhibitor activity [PMID 8515476]
GO_process: cell proliferation [PMID 10767298]; negative regulation of protein kinase activity [PMID 8515476]; regulation of progression through cell cycle [PMID 10767298]; signal transduction [PMID 8515476]
RefSeq accession NP_006133
SwissProt accession P31947
Substrate protein
Gene name RAF1( Description: v-raf-1 murine leukemia viral oncogene homolog 1. )
Synonyms C-RAF; CRAF; EC 2.7.11.1; Raf-1; c-Raf; cRaf
GO annotations GO_component: mitochondrial outer membrane [PMID 8929532]
GO_function:ATP binding; diacylglycerol binding; metal ion binding; nucleotide binding; protein binding [PMID 9624170] [PMID 10433554]; protein serine/threonine kinase activity; receptor signaling protein activity; transferase activity; zinc ion binding
GO_process: apoptosis [PMID 8929532]; cell proliferation [PMID 8063729]; intracellular signaling cascade; protein amino acid phosphorylation [PMID 8063729]
RefSeq accession NP_002871
SwissProt accession P04049
Sequence:(RefSeq accession:NP_002871; substrate region highlighted if known)
1
61
121
181
241
301
361
421
481
541
601
MEHIQGAWKT ISNGFGFKDA VFDGSSCISP TIVQQFGYQR RASDDGKLTD PSKTSNTIRV
FLPNKQRTVV NVRNGMSLHD CLMKALKVRG LQPECCAVFR LLHEHKGKKA RLDWNTDAAS
LIGEELQVDF LDHVPLTTHN FARKTFLKLA FCDICQKFLL NGFRCQTCGY KFHEHCSTKV
PTMCVDWSNI RQLLLFPNST IGDSGVPALP SLTMRRMRES VSRMPVSSQH RYSTPHAFTF
NTSSPSSEGS LSQRQRSTST PNVHMVSTTL PVDSRMIEDA IRSHSESASP SALSSSPNNL
SPTGWSQPKT PVPAQRERAP VSGTQEKNKI RPRGQRDSSY YWEIEASEVM LSTRIGSGSF
GTVYKGKWHG DVAVKILKVV DPTPEQFQAF RNEVAVLRKT RHVNILLFMG YMTKDNLAIV
TQWCEGSSLY KHLHVQETKF QMFQLIDIAR QTAQGMDYLH AKNIIHRDMK SNNIFLHEGL
TVKIGDFGLA TVKSRWSGSQ QVEQPTGSVL WMAPEVIRMQ DNNPFSFQSD VYSYGIVLYE
LMTGELPYSH INNRDQIIFM VGRGYASPDL SKLYKNCPKA MKRLVADCVK KVKEERPLFP
QILSSIELLQ HSLPKINRSA SEPSLHRAAH TEDINACTLT TSPRLPVF
Records:
Category Evidence Reference
A Peptide library McPherson RA, Harding A, Roy S, Lane A, Hancock JF., Interactions of c-Raf-1 with phosphatidylserine and 14-3-3., [10445849]
A Inference Masters SC, Fu H., 14-3-3 proteins mediate an essential anti-apoptotic signal., [11577088]
A Inference Hekman M, Hamm H, Villar AV, Bader B, Kuhlmann J, Nickel J, Rapp UR., Associations of B- and C-Raf with cholesterol, phosphatidylserine, and lipid second messengers: preferential binding of Raf to artificial lipid rafts., [11953426]
A Inference Rajalingam K, Wunder C, Brinkmann V, Churin Y, Hekman M, Sievers C, Rapp UR, Rudel T., Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration., [16041367]
End of Record Details