ul_1605----
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PPBD protein
Gene name PLK1( Description: polo-like kinase 1 (Drosophila). )
Synonyms EC 2.7.11.21; PLK; PLK-1; Polo-like kinase 1; STPK13; Serine/threonine-protein kinase 13
GO annotations GO_component: centrosome [PMID 11256614]; nucleus
GO_function:ATP binding; nucleotide binding; protein binding [PMID 15070733] [PMID 15654075] [PMID 16439210]; protein serine/threonine kinase activity [PMID 8127874]; transferase activity
GO_process: cell proliferation [PMID 8127874]; mitosis [PMID 9177283]; protein amino acid phosphorylation; regulation of progression through cell cycle [PMID 8127874]
RefSeq accession NP_005021
SwissProt accession P53350
Substrate protein
Gene name CDC25C
Synonyms Dual specificity phosphatase Cdc25C; EC 3.1.3.48
GO annotations GO_component: intracellular; nucleus
GO_function:hydrolase activity; protein tyrosine phosphatase activity [PMID 11078813]
GO_process: cell cycle; cell division; cell proliferation [PMID 11139144]; protein amino acid dephosphorylation; regulation of cyclin-dependent protein kinase activity [PMID 11139144]; regulation of mitosis [PMID 1828290]; traversing start control point of mitotic cell cycle [PMID 2195549]
RefSeq accession NP_001781
SwissProt accession P30307
Sequence:(RefSeq accession:NP_001781; substrate region highlighted if known)
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MSTELFSSTR EEGSSGSGPS FRSNQRKMLN LLLERDTSFT VCPDVPRTPV GKFLGDSANL
SILSGGTPKC CLDLSNLSSG EITATQLTTS ADLDETGHLD SSGLQEVHLA GMNHDQHLMK
CSPAQLLCST PNGLDRGHRK RDAMCSSSAN KENDNGNLVD SEMKYLGSPI TTVPKLDKNP
NLGEDQAEEI SDELMEFSLK DQEAKVSRSG LYRSPSMPEN LNRPRLKQVE KFKDNTIPDK
VKKKYFSGQG KLRKGLCLKK TVSLCDITIT QMLEEDSNQG HLIGDFSKVC ALPTVSGKHQ
DLKYVNPETV AALLSGKFQG LIEKFYVIDC RYPYEYLGGH IQGALNLYSQ EELFNFFLKK
PIVPLDTQKR IIIVFHCEFS SERGPRMCRC LREEDRSLNQ YPALYYPELY ILKGGYRDFF
PEYMELCEPQ SYCPMHHQDH KTELLRCRSQ SKVQEGERQL REQIALLVKD MSP
Records:
Category Evidence Reference
A Mutagenesis Elia AE, Cantley LC, Yaffe MB., Mammalian Numb is a target protein of Mdm2, ubiquitin ligase., [12595692]
A Inference Elia AE, Rellos P, Haire LF, Chao JW, Ivins FJ, Hoepker K, Mohammad D, Cantley LC, Smerdon SJ, Yaffe MB., Mammalian Numb is a target protein of Mdm2, ubiquitin ligase., [14532005]
End of Record Details