ul_1609----
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PPBD protein
Gene name PLK1( Description: polo-like kinase 1 (Drosophila). )
Synonyms EC 2.7.11.21; PLK; PLK-1; Polo-like kinase 1; STPK13; Serine/threonine-protein kinase 13
GO annotations GO_component: centrosome [PMID 11256614]; nucleus
GO_function:ATP binding; nucleotide binding; protein binding [PMID 15070733] [PMID 15654075] [PMID 16439210]; protein serine/threonine kinase activity [PMID 8127874]; transferase activity
GO_process: cell proliferation [PMID 8127874]; mitosis [PMID 9177283]; protein amino acid phosphorylation; regulation of progression through cell cycle [PMID 8127874]
RefSeq accession NP_005021
SwissProt accession P53350
Substrate protein
Gene name BUB1( Description: BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast). )
Synonyms BUB1A; BUB1L; EC 2.7.11.1; hBUB1
GO annotations GO_component: kinetochore [PMID 9660858]; nucleus; spindle pole body [PMID 9660858]
GO_function:ATP binding; nucleotide binding; protein serine/threonine kinase activity; transferase activity
GO_process: cell cycle; cell division; cell proliferation [PMID 9790499]; mitosis; mitotic spindle checkpoint [PMID 9790499]; protein amino acid phosphorylation
RefSeq accession NP_004327
SwissProt accession O43683
GO Pathway:
GO:0000776     kinetochore
Sequence:(RefSeq accession:NP_004327; substrate region highlighted if known)
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MDTPENVLQM LEAHMQSYKG NDPLGEWERY IQWVEENFPE NKEYLITLLE HLMKEFLDKK
KYHNDPRFIS YCLKFAEYNS DLHQFFEFLY NHGIGTLSSP LYIAWAGHLE AQGELQHASA
VLQRGIQNQA EPREFLQQQY RLFQTRLTET HLPAQARTSE PLHNVQVLNQ MITSKSNPGN
NMACISKNQG SELSGVISSA CDKESNMERR VITISKSEYS VHSSLASKVD VEQVVMYCKE
KLIRGESEFS FEELRAQKYN QRRKHEQWVN EDRHYMKRKE ANAFEEQLLK QKMDELHKKL
HQVVETSHED LPASQERSEV NPARMGPSVG SQQELRAPCL PVTYQQTPVN MEKNPREAPP
VVPPLANAIS AALVSPATSQ SIAPPVPLKA QTVTDSMFAV ASKDAGCVNK STHEFKPQSG
AEIKEGCETH KVANTSSFHT TPNTSLGMVQ ATPSKVQPSP TVHTKEALGF IMNMFQAPTL
PDISDDKDEW QSLDQNEDAF EAQFQKNVRS SGAWGVNKII SSLSSAFHVF EDGNKENYGL
PQPKNKPTGA RTFGERSVSR LPSKPKEEVP HAEEFLDDST VWGIRCNKTL APSPKSPGDF
TSAAQLASTP FHKLPVESVH ILEDKENVVA KQCTQATLDS CEENMVVPSR DGKFSPIQEK
SPKQALSSHM YSASLLRLSQ PAAGGVLTCE AELGVEACRL TDTDAAIAED PPDAIAGLQA
EWMQMSSLGT VDAPNFIVGN PWDDKLIFKL LSGLSKPVSS YPNTFEWQCK LPAIKPKTEF
QLGSKLVYVH HLLGEGAFAQ VYEATQGDLN DAKNKQKFVL KVQKPANPWE FYIGTQLMER
LKPSMQHMFM KFYSAHLFQN GSVLVGELYS YGTLLNAINL YKNTPEKVMP QGLVISFAMR
MLYMIEQVHD CEIIHGDIKP DNFILGNGFL EQDDEDDLSA GLALIDLGQS IDMKLFPKGT
IFTAKCETSG FQCVEMLSNK PWNYQIDYFG VAATVYCMLF GTYMKVKNEG GECKPEGLFR
RLPHLDMWNE FFHVMLNIPD CHHLPSLDLL RQKLKKVFQQ HYTNKIRALR NRLIVLLLEC
KRSRK
Records:
Category Evidence Reference
A Mutagenesis Qi W, Tang Z, Yu H., Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1., [16760428]
End of Record Details