ul_1628----
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PPBD protein
Gene name CBL( Description: Cas-Br-M (murine) ecotropic retroviral transforming sequence. )
Synonyms C-CBL; CBL2; Casitas B-lineage lymphoma proto-oncogene; EC 6.3.2.-; Proto-oncogene c-CBL; RING finger protein 55; RNF55; Signal transduction protein CBL
GO annotations GO_component: nucleus; plasma membrane [PMID 15465819]
GO_function:calcium ion binding; ligase activity; protein binding [PMID 11891219]; signal transducer activity; transcription factor activity [PMID 2030914]; ubiquitin-protein ligase activity [PMID 15465819]; zinc ion binding
GO_process: cell surface receptor linked signal transduction [PMID 15465819]; epidermal growth factor receptor signaling pathway [PMID 15465819]; intracellular signaling cascade; positive regulation of receptor mediated endocytosis [PMID 15465819]; protein ubiquitination [PMID 15465819]
RefSeq accession NP_005179
SwissProt accession P22681
Substrate protein
Gene name SYK( Description: spleen tyrosine kinase. )
Synonyms EC 2.7.10.2; Spleen tyrosine kinase
GO annotations GO_component: cytoplasm; T cell receptor complex [PMID 8176201]
GO_function:ATP binding; integrin binding [PMID 12885943]; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding [PMID 8627166] [PMID 9280292] [PMID 12885943]; transferase activity
GO_process: cell proliferation [PMID 10963601]; integrin-mediated signaling pathway [PMID 12885943]; intracellular signaling cascade; leukocyte adhesion [PMID 12885943]; neutrophil chemotaxis [PMID 12885943]; organ morphogenesis [PMID 7477352]; protein amino acid phosphorylation [PMID 8163536]; protein complex assembly [PMID 8163536]
RefSeq accession NP_003168
SwissProt accession P43405
Sequence:(RefSeq accession:NP_003168; substrate region highlighted if known)
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601
MASSGMADSA NHLPFFFGNI TREEAEDYLV QGGMSDGLYL LRQSRNYLGG FALSVAHGRK
AHHYTIEREL NGTYAIAGGR THASPADLCH YHSQESDGLV CLLKKPFNRP QGVQPKTGPF
EDLKENLIRE YVKQTWNLQG QALEQAIISQ KPQLEKLIAT TAHEKMPWFH GKISREESEQ
IVLIGSKTNG KFLIRARDNN GSYALCLLHE GKVLHYRIDK DKTGKLSIPE GKKFDTLWQL
VEHYSYKADG LLRVLTVPCQ KIGTQGNVNF GGRPQLPGSH PATWSAGGII SRIKSYSFPK
PGHRKSSPAQ GNRQESTVSF NPYEPELAPW AADKGPQREA LPMDTEVYES PYADPEEIRP
KEVYLDRKLL TLEDKELGSG NFGTVKKGYY QMKKVVKTVA VKILKNEAND PALKDELLAE
ANVMQQLDNP YIVRMIGICE AESWMLVMEM AELGPLNKYL QQNRHVKDKN IIELVHQVSM
GMKYLEESNF VHRDLAARNV LLVTQHYAKI SDFGLSKALR ADENYYKAQT HGKWPVKWYA
PECINYYKFS SKSDVWSFGV LMWEAFSYGQ KPYRGMKGSE VTAMLEKGER MGCPAGCPRE
MYDLMNLCWT YDVENRPGFA AVELRLRNYY YDVVN
Records:
Category Evidence Reference
A Mutagenesis Lupher ML, Rao N, Lill NL, Andoniou CE, Miyake S, Clark EA, Druker B, Band H., Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323., [9857068]
End of Record Details