ul_1631----
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PPBD protein
Gene name CBL( Description: Cas-Br-M (murine) ecotropic retroviral transforming sequence. )
Synonyms C-CBL; CBL2; Casitas B-lineage lymphoma proto-oncogene; EC 6.3.2.-; Proto-oncogene c-CBL; RING finger protein 55; RNF55; Signal transduction protein CBL
GO annotations GO_component: nucleus; plasma membrane [PMID 15465819]
GO_function:calcium ion binding; ligase activity; protein binding [PMID 11891219]; signal transducer activity; transcription factor activity [PMID 2030914]; ubiquitin-protein ligase activity [PMID 15465819]; zinc ion binding
GO_process: cell surface receptor linked signal transduction [PMID 15465819]; epidermal growth factor receptor signaling pathway [PMID 15465819]; intracellular signaling cascade; positive regulation of receptor mediated endocytosis [PMID 15465819]; protein ubiquitination [PMID 15465819]
RefSeq accession NP_005179
SwissProt accession P22681
Substrate protein
Gene name ZAP70( Description: zeta-chain (TCR) associated protein kinase 70kDa. )
Synonyms 70 kDa zeta-associated protein; EC 2.7.10.2; SRK; STD; Syk-related tyrosine kinase; TZK; ZAP-70
GO annotations GO_component: cytoplasm [PMID 12359715]; integral to membrane; membrane; T cell receptor complex [PMID 8176201]
GO_function:ATP binding [PMID 1423621]; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding [PMID 7528772] [PMID 11891219] [PMID 12359715] [PMID 12646565]; protein-tyrosine kinase activity; transferase activity
GO_process: immune response [PMID 1423621]; positive regulation of T cell differentiation [PMID 7630421]; positive thymic T cell selection [PMID 7630421]; protein amino acid phosphorylation [PMID 1423621]; protein kinase cascade [PMID 1423621]
RefSeq accession NP_001070
SwissProt accession P43403
Sequence:(RefSeq accession:NP_001070; substrate region highlighted if known)
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601
MPDPAAHLPF FYGSISRAEA EEHLKLAGMA DGLFLLRQCL RSLGGYVLSL VHDVRFHHFP
IERQLNGTYA IAGGKAHCGP AELCEFYSRD PDGLPCNLRK PCNRPSGLEP QPGVFDCLRD
AMVRDYVRQT WKLEGEALEQ AIISQAPQVE KLIATTAHER MPWYHSSLTR EEAERKLYSG
AQTDGKFLLR PRKEQGTYAL SLIYGKTVYH YLISQDKAGK YCIPEGTKFD TLWQLVEYLK
LKADGLIYCL KEACPNSSAS NASGAAAPTL PAHPSTLTHP QRRIDTLNSD GYTPEPARIT
SPDKPRPMPM DTSVYESPYS DPEELKDKKL FLKRDNLLIA DIELGCGNFG SVRQGVYRMR
KKQIDVAIKV LKQGTEKADT EEMMREAQIM HQLDNPYIVR LIGVCQAEAL MLVMEMAGGG
PLHKFLVGKR EEIPVSNVAE LLHQVSMGMK YLEEKNFVHR DLAARNVLLV NRHYAKISDF
GLSKALGADD SYYTARSAGK WPLKWYAPEC INFRKFSSRS DVWSYGVTMW EALSYGQKPY
KKMKGPEVMA FIEQGKRMEC PPECPPELYA LMSDCWIYKW EDRPDFLTVE QRMRACYYSL
ASKVEGPPGS TQKAEAACA
Records:
Category Evidence Reference
A Inference van Leeuwen JE, Paik PK, Samelson LE., The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells., [10490604]
End of Record Details