ul_1637----
Record details: Hide
PPBD protein
Gene name DAB1( Description: dishevelled associated activator of morphogenesis 2. )
Synonyms KIAA0381; MGC90515; RP1-278E11.1; dJ90A20A.1
GO annotations GO_component:
GO_function:
GO_process: cell differentiation; nervous system development
RefSeq accession NP_066566
SwissProt accession O75553
Substrate protein
Gene name LDLR( Description: low density lipoprotein receptor (familial hypercholesterolemia). )
Synonyms FH; FHC
GO annotations GO_component: coated pit; integral to plasma membrane [PMID 6327078]; plasma membrane [PMID 2777800]
GO_function:calcium ion binding; lipid transporter activity; lipoprotein binding [PMID 6091915]; low-density lipoprotein receptor activity [PMID 2777800]; transmembrane receptor activity [PMID 6091915]
GO_process: cholesterol metabolism; endocytosis [PMID 12671190]; lipid metabolism [PMID 6299582] [PMID 10827173]; lipid transport; protein amino acid O-linked glycosylation [PMID 6091915]; steroid metabolism
RefSeq accession NP_000518
SwissProt accession P01130
Sequence:(RefSeq accession:NP_000518; substrate region highlighted if known)
1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
MGPWGWKLRW TVALLLAAAG TAVGDRCERN EFQCQDGKCI SYKWVCDGSA ECQDGSDESQ
ETCLSVTCKS GDFSCGGRVN RCIPQFWRCD GQVDCDNGSD EQGCPPKTCS QDEFRCHDGK
CISRQFVCDS DRDCLDGSDE ASCPVLTCGP ASFQCNSSTC IPQLWACDND PDCEDGSDEW
PQRCRGLYVF QGDSSPCSAF EFHCLSGECI HSSWRCDGGP DCKDKSDEEN CAVATCRPDE
FQCSDGNCIH GSRQCDREYD CKDMSDEVGC VNVTLCEGPN KFKCHSGECI TLDKVCNMAR
DCRDWSDEPI KECGTNECLD NNGGCSHVCN DLKIGYECLC PDGFQLVAQR RCEDIDECQD
PDTCSQLCVN LEGGYKCQCE EGFQLDPHTK ACKAVGSIAY LFFTNRHEVR KMTLDRSEYT
SLIPNLRNVV ALDTEVASNR IYWSDLSQRM ICSTQLDRAH GVSSYDTVIS RDIQAPDGLA
VDWIHSNIYW TDSVLGTVSV ADTKGVKRKT LFRENGSKPR AIVVDPVHGF MYWTDWGTPA
KIKKGGLNGV DIYSLVTENI QWPNGITLDL LSGRLYWVDS KLHSISSIDV NGGNRKTILE
DEKRLAHPFS LAVFEDKVFW TDIINEAIFS ANRLTGSDVN LLAENLLSPE DMVLFHNLTQ
PRGVNWCERT TLSNGGCQYL CLPAPQINPH SPKFTCACPD GMLLARDMRS CLTEAEAAVA
TQETSTVRLK VSSTAVRTQH TTTRPVPDTS RLPGATPGLT TVEIVTMSHQ ALGDVAGRGN
EKKPSSVRAL SIVLPIVLLV FLCLGVFLLW KNWRLKNINS INFDNPVYQK TTEDEVHICH
NQDGYSYPSR QMVSLEDDVA
Records:
Category Evidence Reference
A Peptide library Morris SM, Cooper JA., Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation., [11247302]
End of Record Details