ul_1641----
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PPBD protein
Gene name DAB1( Description: dishevelled associated activator of morphogenesis 2. )
Synonyms KIAA0381; MGC90515; RP1-278E11.1; dJ90A20A.1
GO annotations GO_component:
GO_function:
GO_process: cell differentiation; nervous system development
RefSeq accession NP_066566
SwissProt accession O75553
Substrate protein
Gene name INPP5D( Description: inositol polyphosphate-5-phosphatase, 145kDa. )
Synonyms EC 3.1.3.-; Inositol polyphosphate-5-phosphatase of 145 kDa; MGC104855; MGC142140; MGC142142; SH2 domain-containing inositol phosphatase 1; SH2 domain-containing inositol-5'-phosphatase 1; SHIP; SHIP-1; SHIP1; SIP-145; hp51CN; p150Ship
GO annotations GO_component:
GO_function:inositol or phosphatidylinositol phosphatase activity; inositol-polyphosphate 5-phosphatase activity [PMID 8769125]
GO_process: intracellular signaling cascade; phosphate metabolism [PMID 8769125]
RefSeq accession NP_005532
SwissProt accession O00145
Sequence:(RefSeq accession:NP_005532; substrate region highlighted if known)
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1021
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1141
MVPCWNHGNI TRSKAEELLS RTGKDGSFLV RASESISRAY ALCVLYRNCV YTYRILPNED
DKFTVQASEG VSMRFFTKLD QLIEFYKKEN MGLVTHLQYP VPLEEEDTGD DPEEDTESVV
SPPELPPRNI PLTASSCEAK EVPFSNENPR ATETSRPSLS ETLFQRLQSM DTSGLPEEHL
KAIQDYLSTQ LAQDSEFVKT GSSSLPHLKK LTTLLCKELY GEVIRTLPSL ESLQRLFDQQ
LSPGLRPRPQ VPGEANPINM VSKLSQLTSL LSSIEDKVKA LLHEGPESPH RPSLIPPVTF
EVKAESLGIP QKMQLKVDVE SGKLIIKKSK DGSEDKFYSH KKILQLIKSQ KFLNKLVILV
ETEKEKILRK EYVFADSKKR EGFCQLLQQM KNKHSEQPEP DMITIFIGTW NMGNAPPPKK
ITSWFLSKGQ GKTRDDSADY IPHDIYVIGT QEDPLSEKEW LEILKHSLQE ITSVTFKTVA
IHTLWNIRIV VLAKPEHENR ISHICTDNVK TGIANTLGNK GAVGVSFMFN GTSLGFVNSH
LTSGSEKKLR RNQNYMNILR FLALGDKKLS PFNITHRFTH LFWFGDLNYR VDLPTWEAET
IIQKIKQQQY ADLLSHDQLL TERREQKVFL HFEEEEITFA PTYRFERLTR DKYAYTKQKA
TGMKYNLPSW CDRVLWKSYP LVHVVCQSYG STSDIMTSDH SPVFATFEAG VTSQFVSKNG
PGTVDSQGQI EFLRCYATLK TKSQTKFYLE FHSSCLESFV KSQEGENEEG SEGELVVKFG
ETLPKLKPII SDPEYLLDQH ILISIKSSDS DESYGEGCIA LRLEATETQL PIYTPLTHHG
ELTGHFQGEI KLQTSQGKTR EKLYDFVKTE RDESSGPKTL KSLTSHDPMK QWEVTSRAPP
CSGSSITEII NPNYMGVGPF GPPMPLHVKQ TLSPDQQPTA WSYDQPPKDS PLGPCRGESP
PTPPGQPPIS PKKFLPSTAN RGLPPRTQES RPSDLGKNAG DTLPQEDLPL TKPEMFENPL
YGSLSSFPK
P APRKDQESPK MPRKEPPPCP EPGILSPSIV LTKAQEADRG EGPGKQVPAP
RLRSFTCSSS AEGRAAGGDK SQGKPKTPVS SQAPVPAKRP IKPSRSEINQ QTPPTPTPRP
PLPVKSPAVL HLQHSKGRDY RDNTELPHHG KHRPEEGPPG PLGRTAMQ
Records:
Category Evidence Reference
A Peptide library Morris SM, Cooper JA., Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation., [11247302]
End of Record Details