ul_1664----
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PPBD protein
Gene name FRS2( Description: fibroblast growth factor receptor substrate 2. )
Synonyms FGFR substrate 2; FGFR-signaling adaptor SNT; FRS2A; FRS2alpha; SNT; SNT-1; SNT1; Suc1-associated neurotrophic factor target 1
GO annotations GO_component: integral to plasma membrane [PMID 9660748]; membrane; membrane fraction [PMID 9660748]
GO_function:insulin receptor binding; phosphatase activator activity [PMID 9660748]; protein binding [PMID 9660748]; regulator of G-protein signaling activity [PMID 9660748]; transmembrane receptor protein tyrosine kinase adaptor protein activity [PMID 9660748]
GO_process: fibroblast growth factor receptor signaling pathway [PMID 9660748]; G-protein coupled receptor protein signaling pathway [PMID 9660748]; transmembrane receptor protein tyrosine phosphatase signaling pathway [PMID 9660748]
RefSeq accession NP_006645
SwissProt accession Q8WU20
Substrate protein
Gene name NTRK1( Description: neurotrophic tyrosine kinase, receptor, type 1. )
Synonyms DKFZp781I14186; EC 2.7.10.1; MTC; Neurotrophic tyrosine kinase receptor type 1; TRK; TRK1; TRK1-transforming tyrosine kinase protein; TRKA; Trk-A; p140-TrkA
GO annotations GO_component: cytoplasm; integral to membrane; integral to plasma membrane [PMID 9290260]; membrane
GO_function:ATP binding; kinase activity; neurotrophin binding [PMID 9290260]; nucleotide binding; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity [PMID 1695324] [PMID 1695324] [PMID 8957089]
GO_process: cell differentiation; nervous system development; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway [PMID 9290260]
RefSeq accession NP_002520
SwissProt accession P04629
Sequence:(RefSeq accession:NP_002520; substrate region highlighted if known)
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MLRGGRRGQL GWHSWAAGPG SLLAWLILAS AGAAPCPDAC CPHGSSGLRC TRDGALDSLH
HLPGAENLTE LYIENQQHLQ HLELRDLRGL GELRNLTIVK SGLRFVAPDA FHFTPRLSRL
NLSFNALESL SWKTVQGLSL QELVLSGNPL HCSCALRWLQ RWEEEGLGGV PEQKLQCHGQ
GPLAHMPNAS CGVPTLKVQV PNASVDVGDD VLLRCQVEGR GLEQAGWILT ELEQSATVMK
SGGLPSLGLT LANVTSDLNR KNVTCWAEND VGRAEVSVQV NVSFPASVQL HTAVEMHHWC
IPFSVDGQPA PSLRWLFNGS VLNETSFIFT EFLEPAANET VRHGCLRLNQ PTHVNNGNYT
LLAANPFGQA SASIMAAFMD NPFEFNPEDP IPVSFSPVDT NSTSGDPVEK KDETPFGVSV
AVGLAVFACL FLSTLLLVLN KCGRRNKFGI NRPAVLAPED GLAMSLHFMT LGGSSLSPTE
GKGSGLQGHI IENPQYFSDA CVHHIKRRDI VLKWELGEGA FGKVFLAECH NLLPEQDKML
VAVKALKEAS ESARQDFQRE AELLTMLQHQ HIVRFFGVCT EGRPLLMVFE YMRHGDLNRF
LRSHGPDAKL LAGGEDVAPG PLGLGQLLAV ASQVAAGMVY LAGLHFVHRD LATRNCLVGQ
GLVVKIGDFG MSRDIYSTDY YRVGGRTMLP IRWMPPESIL YRKFTTESDV WSFGVVLWEI
FTYGKQPWYQ LSNTEAIDCI TQGRELERPR ACPPEVYAIM RGCWQREPQQ RHSIKDVHAR
LQALAQAPPV YLDVLG
Records:
Category Evidence Reference
A Peptide library Ong SH, Guy GR, Hadari YR, Laks S, Gotoh N, Schlessinger J, Lax I., FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors., [10629055]
A Peptide library Yan KS, Kuti M, Yan S, Mujtaba S, Farooq A, Goldfarb MP, Zhou MM., FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors., [11877385]
End of Record Details