ul_1666----
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PPBD protein
Gene name FRS2( Description: fibroblast growth factor receptor substrate 2. )
Synonyms FGFR substrate 2; FGFR-signaling adaptor SNT; FRS2A; FRS2alpha; SNT; SNT-1; SNT1; Suc1-associated neurotrophic factor target 1
GO annotations GO_component: integral to plasma membrane [PMID 9660748]; membrane; membrane fraction [PMID 9660748]
GO_function:insulin receptor binding; phosphatase activator activity [PMID 9660748]; protein binding [PMID 9660748]; regulator of G-protein signaling activity [PMID 9660748]; transmembrane receptor protein tyrosine kinase adaptor protein activity [PMID 9660748]
GO_process: fibroblast growth factor receptor signaling pathway [PMID 9660748]; G-protein coupled receptor protein signaling pathway [PMID 9660748]; transmembrane receptor protein tyrosine phosphatase signaling pathway [PMID 9660748]
RefSeq accession NP_006645
SwissProt accession Q8WU20
Substrate protein
Gene name RET
Synonyms C-ret; EC 2.7.10.1
GO annotations GO_component: integral to membrane; membrane
GO_function:ATP binding; calcium ion binding; nucleotide binding; protein-tyrosine kinase activity [PMID 7824936]; receptor activity [PMID 7824936]; transferase activity
GO_process: cell surface receptor linked signal transduction; homophilic cell adhesion; posterior midgut development [PMID 8114939]; protein amino acid phosphorylation [PMID 7824936]; signal transduction [PMID 7824936]
RefSeq accession NP_066124
SwissProt accession P07949
Sequence:(RefSeq accession:NP_066124; substrate region highlighted if known)
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MAKATSGAAG LRLLLLLLLP LLGKVALGLY FSRDAYWEKL YVDQAAGTPL LYVHALRDAP
EEVPSFRLGQ HLYGTYRTRL HENNWICIQE DTGLLYLNRS LDHSSWEKLS VRNRGFPLLT
VYLKVFLSPT SLREGECQWP GCARVYFSFF NTSFPACSSL KPRELCFPET RPSFRIRENR
PPGTFHQFRL LPVQFLCPNI SVAYRLLEGE GLPFRCAPDS LEVSTRWALD REQREKYELV
AVCTVHAGAR EEVVMVPFPV TVYDEDDSAP TFPAGVDTAS AVVEFKRKED TVVATLRVFD
ADVVPASGEL VRRYTSTLLP GDTWAQQTFR VEHWPNETSV QANGSFVRAT VHDYRLVLNR
NLSISENRTM QLAVLVNDSD FQGPGAGVLL LHFNVSVLPV SLHLPSTYSL SVSRRARRFA
QIGKVCVENC QAFSGINVQY KLHSSGANCS TLGVVTSAED TSGILFVNDT KALRRPKCAE
LHYMVVATDQ QTSRQAQAQL LVTVEGSYVA EEAGCPLSCA VSKRRLECEE CGGLGSPTGR
CEWRQGDGKG ITRNFSTCSP STKTCPDGHC DVVETQDINI CPQDCLRGSI VGGHEPGEPR
GIKAGYGTCN CFPEEEKCFC EPEDIQDPLC DELCRTVIAA AVLFSFIVSV LLSAFCIHCY
HKFAHKPPIS SAEMTFRRPA QAFPVSYSSS GARRPSLDSM ENQVSVDAFK ILEDPKWEFP
RKNLVLGKTL GEGEFGKVVK ATAFHLKGRA GYTTVAVKML KENASPSELR DLLSEFNVLK
QVNHPHVIKL YGACSQDGPL LLIVEYAKYG SLRGFLRESR KVGPGYLGSG GSRNSSSLDH
PDERALTMGD LISFAWQISQ GMQYLAEMKL VHRDLAARNI LVAEGRKMKI SDFGLSRDVY
EEDSYVKRSQ GRIPVKWMAI ESLFDHIYTT QSDVWSFGVL LWEIVTLGGN PYPGIPPERL
FNLLKTGHRM ERPDNCSEEM YRLMLQCWKQ EPDKRPVFAD ISKDLEKMMV KRRDYLDLAA
STPSDSLIYD DGLSEEETPL VDCNNAPLPR ALPSTWIENK LYGMSDPNWP GESPVPLTRA
DGTNTGFPRY PNDSVYANWM LSPSAAKLMD TFDS
Records:
Category Evidence Reference
A Mutagenesis Kurokawa K, Iwashita T, Murakami H, Hayashi H, Kawai K, Takahashi M., Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction., [11360177]
End of Record Details