ul_1669----
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PPBD protein
Gene name FRS2( Description: fibroblast growth factor receptor substrate 2. )
Synonyms FGFR substrate 2; FGFR-signaling adaptor SNT; FRS2A; FRS2alpha; SNT; SNT-1; SNT1; Suc1-associated neurotrophic factor target 1
GO annotations GO_component: integral to plasma membrane [PMID 9660748]; membrane; membrane fraction [PMID 9660748]
GO_function:insulin receptor binding; phosphatase activator activity [PMID 9660748]; protein binding [PMID 9660748]; regulator of G-protein signaling activity [PMID 9660748]; transmembrane receptor protein tyrosine kinase adaptor protein activity [PMID 9660748]
GO_process: fibroblast growth factor receptor signaling pathway [PMID 9660748]; G-protein coupled receptor protein signaling pathway [PMID 9660748]; transmembrane receptor protein tyrosine phosphatase signaling pathway [PMID 9660748]
RefSeq accession NP_006645
SwissProt accession Q8WU20
Substrate protein
Gene name NTRK2( Description: neurotrophic tyrosine kinase, receptor, type 2. )
Synonyms EC 2.7.10.1; GP145-TrkB; Neurotrophic tyrosine kinase receptor type 2; TRKB; Trk-B; TrkB tyrosine kinase
GO annotations GO_component: integral to plasma membrane [PMID 1710174]; membrane
GO_function:ATP binding; kinase activity; neurotrophin binding [PMID 1710174]; nucleotide binding; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity
GO_process: cell differentiation; nervous system development; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway [PMID 1710174]
RefSeq accession NP_006171
SwissProt accession Q16620
Sequence:(RefSeq accession:NP_006171; substrate region highlighted if known)
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MSSWIRWHGP AMARLWGFCW LVVGFWRAAF ACPTSCKCSA SRIWCSDPSP GIVAFPRLEP
NSVDPENITE IFIANQKRLE IINEDDVEAY VGLRNLTIVD SGLKFVAHKA FLKNSNLQHI
NFTRNKLTSL SRKHFRHLDL SELILVGNPF TCSCDIMWIK TLQEAKSSPD TQDLYCLNES
SKNIPLANLQ IPNCGLPSAN LAAPNLTVEE GKSITLSCSV AGDPVPNMYW DVGNLVSKHM
NETSHTQGSL RITNISSDDS GKQISCVAEN LVGEDQDSVN LTVHFAPTIT FLESPTSDHH
WCIPFTVKGN PKPALQWFYN GAILNESKYI CTKIHVTNHT EYHGCLQLDN PTHMNNGDYT
LIAKNEYGKD EKQISAHFMG WPGIDDGANP NYPDVIYEDY GTAANDIGDT TNRSNEIPST
DVTDKTGREH LSVYAVVVIA SVVGFCLLVM LFLLKLARHS KFGMKDFSWF GFGKVKSRQG
VGPASVISND DDSASPLHHI SNGSNTPSSS EGGPDAVIIG MTKIPVIENP QYFGITNSQL
KPDTFVQHIK RHNIVLKREL GEGAFGKVFL AECYNLCPEQ DKILVAVKTL KDASDNARKD
FHREAELLTN LQHEHIVKFY GVCVEGDPLI MVFEYMKHGD LNKFLRAHGP DAVLMAEGNP
PTELTQSQML HIAQQIAAGM VYLASQHFVH RDLATRNCLV GENLLVKIGD FGMSRDVYST
DYYRVGGHTM LPIRWMPPES IMYRKFTTES DVWSLGVVLW EIFTYGKQPW YQLSNNEVIE
CITQGRVLQR PRTCPQEVYE LMLGCWQREP HMRKNIKGIH TLLQNLAKAS PVYLDILG
Records:
Category Evidence Reference
A Peptide library Yan KS, Kuti M, Yan S, Mujtaba S, Farooq A, Goldfarb MP, Zhou MM., FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors., [11877385]
End of Record Details