ul_1670----

Record details:

PPBD protein

Gene name	FRS2( Description: fibroblast growth factor receptor substrate 2. )
Synonyms	FGFR substrate 2; FGFR-signaling adaptor SNT; FRS2A; FRS2alpha; SNT; SNT-1; SNT1; Suc1-associated neurotrophic factor target 1
GO annotations	GO_component: integral to plasma membrane [PMID 9660748]; membrane; membrane fraction [PMID 9660748] GO_function:insulin receptor binding; phosphatase activator activity [PMID 9660748]; protein binding [PMID 9660748]; regulator of G-protein signaling activity [PMID 9660748]; transmembrane receptor protein tyrosine kinase adaptor protein activity [PMID 9660748] GO_process: fibroblast growth factor receptor signaling pathway [PMID 9660748]; G-protein coupled receptor protein signaling pathway [PMID 9660748]; transmembrane receptor protein tyrosine phosphatase signaling pathway [PMID 9660748]
RefSeq accession	NP_006645
SwissProt accession	Q8WU20

Substrate protein

Gene name	IL4R( Description: interleukin 4 receptor. )
Synonyms	CD124; CD124 antigen; IL-4R-alpha; IL4RA
GO annotations	GO_component: integral to plasma membrane [PMID 2307934]; membrane GO_function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-4 receptor activity [PMID 2307934]; protein binding [PMID 8266078]; receptor activity; receptor signaling protein activity [PMID 2307934] GO_process: immune response [PMID 2307934]; signal transduction [PMID 2307934]
RefSeq accession	NP_000409
SwissProt accession	P24394

Sequence:(RefSeq accession:NP_000409; substrate region highlighted if known)

1
61
121
181
241
301
361
421
481
541
601
661
721
781

MGWLCSGLLF PVSCLVLLQV ASSGNMKVLQ EPTCVSDYMS ISTCEWKMNG PTNCSTELRL
LYQLVFLLSE AHTCIPENNG GAGCVCHLLM DDVVSADNYT LDLWAGQQLL WKGSFKPSEH
VKPRAPGNLT VHTNVSDTLL LTWSNPYPPD NYLYNHLTYA VNIWSENDPA DFRIYNVTYL
EPSLRIAAST LKSGISYRAR VRAWAQCYNT TWSEWSPSTK WHNSYREPFE QHLLLGVSVS
CIVILAVCLL CYVSITKIKK EWWDQIPNPA RSRLVAIIIQ DAQGSQWEKR SRGQEPAKCP
HWKNCLTKLL PCFLEHNMKR DEDPHKAAKE MPFQGSGKSA WCPVEISKTV LWPESISVVR
CVELFEAPVE CEEEEEVEEE KGSFCASPES SRDDFQEGRE GIVARLTESL FLDLLGEENG
GFCQQDMGES CLLPPSGSTS AHMPWDEFPS AGPKEAPPWG KEQPLHLEPS PPASPTQSPD
NLTCTETPLV IAGNPAYRSF SNSLSQSPCP RELGPDPLLA RHLEEVEPEM PCVPQLSEPT
TVPQPEPETW EQILRRNVLQ HGAAAAPVSA PTSGYQEFVH AVEQGGTQAS AVVGLGPPGE
AGYKAFSSLL ASSAVSPEKC GFGASSGEEG YKPFQDLIPG CPGDPAPVPV PLFTFGLDRE
PPRSPQSSHL PSSSPEHLGL EPGEKVEDMP KPPLPQEQAT DPLVDSLGSG IVYSALTCHL
CGHLKQCHGQ EDGGQTPVMA SPCCGCCCGD RSSPPTTPLR APDPSPGGVP LEASLCPASL
APSGISEKSK SSSSFHPAPG NAQSSSQTPK IVNFVSVGPT YMRVS

Records:

Category	Evidence	Reference
A	Peptide library	Yan KS, Kuti M, Yan S, Mujtaba S, Farooq A, Goldfarb MP, Zhou MM., FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors., [11877385]

End of Record Details